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Objective:To evaluate the quality of a systematic review/Meta-analysis of auricular acupressure on pain, and provide decision making basis for Traditional Chinese Medicine (TCM) nursing.Methods:PubMed, Embase, Web of Science, Cochrane Library, CINAHL, CNKI, Wanfang Data, VIP, CBM databases were searched to collect systematic reviews or Meta-analysis on auricular acupressure intervention pain from inception to October, 2020. Two researchers independently screened literature, extracted the data, and used AMSTAR 2 and GRADE to evaluate methodological quality and evidence quality.Results:A total of 8 systematic reviews were included. The AMSTAT2 evaluation showed that all the studies were in low methodological quality; GRADE tool graded 26 outcome indicators, including 6 intermediate quality indicators, 16 low-level quality indicatorsand 4 extremely low-level quality indicators. The research results showed that auricular acupressure is safe and effective in chronic low back pain, primary dysmenorrhea and partial postoperative pain. Another study found that it has no significant effect, but it can reduce the rate of adverse reactions.Conclusions:These studies show that auricular acupressure is safe on pain and has certain advantages, but its methodological quality and evidence quality are not high, which requires further research to confirm.
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Affective brain-computer interfaces (aBCIs) has important application value in the field of human-computer interaction. Electroencephalogram (EEG) has been widely concerned in the field of emotion recognition due to its advantages in time resolution, reliability and accuracy. However, the non-stationary characteristics and individual differences of EEG limit the generalization of emotion recognition model in different time and different subjects. In this paper, in order to realize the recognition of emotional states across different subjects and sessions, we proposed a new domain adaptation method, the maximum classifier difference for domain adversarial neural networks (MCD_DA). By establishing a neural network emotion recognition model, the shallow feature extractor was used to resist the domain classifier and the emotion classifier, respectively, so that the feature extractor could produce domain invariant expression, and train the decision boundary of classifier learning task specificity while realizing approximate joint distribution adaptation. The experimental results showed that the average classification accuracy of this method was 88.33% compared with 58.23% of the traditional general classifier. It improves the generalization ability of emotion brain-computer interface in practical application, and provides a new method for aBCIs to be used in practice.
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Humans , Algorithms , Brain-Computer Interfaces , Electroencephalography , Emotions , Reproducibility of ResultsABSTRACT
With the wide application of virtual reality technology and the rapid popularization of virtual reality devices, the problem of brain fatigue caused by prolonged use has attracted wide attention. Sixteen healthy subjects were selected in this study. And electroencephalogram (EEG) signals were acquired synchronously while the subjects watch videos in similar types presented by traditional displayer and virtual reality separately. Two questionnaires were conducted by all subjects to evaluate the state of fatigue before and after the experiment. The mutual correlation method was selected to construct the mutual correlation brain network of EEG signals before and after watching videos in two modes. We also calculated the mutual correlation coefficient matrix and the mutual correlation binary matrix and compared the average of degree, clustering coefficient, path length, global efficiency and small world attribute during two experiments. The results showed that the subjects were easier to get fatigue by watching virtual reality video than watching video presented by traditional displayer in a certain period of time. By comparing the characteristic parameters of brain network before and after watching videos, it was found that the average degree value, the average clustering coefficient, the average global efficiency and the small world attribute decreases while the average path length value increased significantly. In addition, compared to traditional plane video, the characteristic parameters of brain network changed more greatly after watching the virtual reality video with a significant difference ( < 0.05). This study can provide theoretical basis and experimental reference for analyzing and evaluating brain fatigue induced by virtual reality visual experience.
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Humans , Brain , Physiology , Electroencephalography , Healthy Volunteers , Mental Fatigue , Virtual RealityABSTRACT
Repetitive transcranial magnetic stimulation(rTMS) is a painless and non-invasive method for stimulation and modulation in the field of cognitive neuroscience research and clinical neurological regulation. In this paper, adult Wistar rats were divided into the rTMS group and control group randomly. Rats in the rTMS group were stimulated with 5 Hz rTMS for 14 days, while the rats in the control group did not accept any stimulation. Then, the behavior and local field potentials (LFPs) were recorded synchronously when the rats perform a working memory (WM) task with T-maze. Finally, the time-frequency distribution and coherence characteristics of the LFPs signal in the prefrontal cortex (PFC) during working memory task were analyzed. The results showed that the rats in the rTMS group needed less training days to reach the task correction criterion than the control group (
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Animals , Rats , Memory, Short-Term , Neurons , Prefrontal Cortex , Rats, Wistar , Transcranial Magnetic StimulationABSTRACT
The study aims to use CRISPR/Cas9 introducing foreign gene targeted knock-in into chicken EAV-HP genome. First, specific primers were designed for amplification of EAV-HP left, right homologous arms and enhanced green fluorescent protein (eGFP) expression cassette. PCR products of homologous arms were ligated to both sides of eGFP by overlap extension PCR, resulting in full-length donor DNA fragment designated as LER. Then LER fragments were cloned into pMD19-T to obtain donor vector pMDT-LER. Subsequently, the donor vector pMDT-LER was transfected into HEK293T cells to verify the expression of eGFP gene. Furthermore, co-transfection of CRISPR/Cas9 expression vector and pMDT-LER into chicken DF-1 cells was performed to achieve eGFP transgenic cells. Meanwhile, eGFP expression was observed in cells, and the event of eGFP integration into EAV-HP genome was detectable by amplification of target DNA. Finally, the transgenic DF-1 cells were passaged seven times, and the stable integration and expression of eGFP was checked by PCR and Western blotting. These results demonstrated that eGFP gene was knocked into the EAV-HP genome successfully, which provides a new integration site for research of transgenic chicken.
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Animals , Humans , CRISPR-Cas Systems , Chickens , Clustered Regularly Interspaced Short Palindromic Repeats , Gene Knock-In Techniques , Genome , HEK293 CellsABSTRACT
Objective@#To investigate the effectiveness of excise training on cancer-related fatigue (CRF) and quality of life (QOL) in patients undergoing anticancer treatment.@*Methods@#Eight databases (PubMed, Medline, Cochran Library, EMBASE, and four Chinese database) were searched to identify randomized controlled trials (RCTs) that evaluated the effects of excise training on CRF and QOL. The quality of literature was strictly evaluated and data extracted by 2 researchers. Meta-analysis was performed on randomized controlled trials that met the quality criteria.@*Results@#Nine RCTs involving 847 patients were included. Pooled results suggested that aerobic exercise can improve the QOL (SMD=1.17, P=0.002), alleviate the symptoms of CRF (SMD=-1.14, P=0.000 2), and also have a certain effect within 3-4 weeks after intervention (P < 0.05); resistance training or anti resistance exercise combined with aerobic exercise can not alleviate the patients′ cancer induced fatigue symptoms (SMD=-0.06, P=0.85), but it can improve the quality of life (SMD=0.39, P=0.002).@*Conclusion@#Patients with anticancer therapy should undergo aerobic exercise under the guidance of professional personnel to alleviate symptoms of cancer-related fatigue and improve their quality of life.
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Objective To investigate the effectiveness of excise training on cancer-related fatigue (CRF) and quality of life (QOL) in patients undergoing anticancer treatment. Methods Eight databases (PubMed, Medline, Cochran Library, EMBASE, and four Chinese database)were searched to identify randomized controlled trials (RCTs) that evaluated the effects of excise training on CRF and QOL. The quality of literature was strictly evaluated and data extracted by 2 researchers. Meta-analysis was performed on randomized controlled trials that met the quality criteria. Results Nine RCTs involving 847 patients were included. Pooled results suggested that aerobic exercise can improve the QOL ( SMD=1.17, P=0.002), alleviate the symptoms of CRF ( SMD=-1.14, P=0.000 2), and also have a certain effect within 3-4 weeks after intervention (P < 0.05); resistance training or anti resistance exercise combined with aerobic exercise can not alleviate the patients′ cancer induced fatigue symptoms ( SMD=-0.06, P=0.85), but it can improve the quality of life ( SMD=0.39, P=0.002). Conclusion Patients with anticancer therapy should undergo aerobic exercise under the guidance of professional personnel to alleviate symptoms of cancer-related fatigue and improve their quality of life.
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Objective To evaluate the influencing factors and early recovery quality in elderly patients with gastrointestinal tumor resection by the quality of recovery-40 questionnaire (QoR-40 questionnaire). Methods One hundred and forty- two elderly patients who had underwent gastrointestinal tumor resection from February to June 2017 were selected. The patients were over 65 years old. Their body mass index was (22.98 ± 3.20) kg/m2, and American Society of Anesthesilogists (ASA) wasⅡorⅢgrade. The patients were assessed with QoR-40 questionnaire on the first and second day after operation, and the factors affecting the total score of QoR-40 questionnaire on the first and second day after operation were analyzed. Results Compared with those on the first day after operation, the scores of emotional status, physical comfort, psychological support, physical independence, pain and total score of QoR-40 questionnaire on the second day after operation were significantly higher: 42 (39, 43) scores vs. 40 (38, 42) scores, 53 (52, 54) scores vs. 52 (50, 53) scores, 35 (35, 35) scores vs. 35 (34, 35) scores, 15 (13, 15) scores vs. 14 (12, 15) scores, 34 (33, 35) scores vs. 33 (32, 34) scores and 178 (173, 182) scores vs. 174 (169, 177) scores, and there were statistical differences (P<0.01). On the first day after operation, the total score of the QoR-40 questionnaire was related with the type of operation (P<0.05), and it was not related with age, sex and anesthesia (P>0.05);on the second day after operation, the total score of QoR-40 questionnaire was related with age and operation type (P<0.05), and it was not related with sex and anesthesia (P > 0.05). Conclusions The early postoperative period score of QoR-40 questionnaire in patients with colorectal tumor resection and age less than 70 years old is higher, and the recovery quality after operation is relatively good, suggesting that the operation type and age may be an important factor affecting the early recovery quality of the elderly patients with gastrointestinal tumor resection.
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With the development of China's economy and aging of the population,patient's demands for nursing are increasingly high,thus it is very important to cultivate high-end and practical nursing personnel.This paper analyzes the necessity and feasibility of the development of Nurse Practitioner in China,and explores the qualifications and management of Nurse Practitioner,the job content of Nurse Practitioner,and the training of Nurse Practitioner.
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Objective To explore the effect of individualized nutritional nurses involved in intervention on quality of life for cancer patients. Methods The articles were searched by Chinese full- text periodical database, Wanfang database, VIP database, PubMed, Cochran Library from 1995 to July 1 2015, and the articles and data were extracted by two researchers using Cochrane systematic review methods using RevMan5. 3 Meta- analysis software. Results The final results included five randomized controlled study, 358 cases of patients. Individualized nutritional quality of life of patients in the intervention group compared with the usual care group, within three months 27.76 points high quality of life, MD = 27.76,95% CI was 8.83-46.68; three months of life high quality 31.64 points, MD = 31.64, 95% CI was 9.70-53.59,6 months or more (including 6- month) high quality of life 34.26 points, MD = 34.26, 95% CI was 3.69-64.84, were statistically significant (P<0.05). Conclusions Nurse participation can improve the quality of life of patients and long-term effects also have some role in promoting. Due to the limitations of this study we need more high quality randomized controlled studies and Meta analysis to verify.
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To explore the self-organization robustness of the biological neural network, and thus to provide new ideas and methods for the electromagnetic bionic protection, we studied both the information transmission mechanism of neural network and spike timing-dependent plasticity (STDP) mechanism, and then investigated the relationship between synaptic plastic and adaptive characteristic of biology. Then a feedforward neural network with the Izhikevich model and the STDP mechanism was constructed, and the adaptive robust capacity of the network was analyzed. Simulation results showed that the neural network based on STDP mechanism had good rubustness capacity, and this characteristics is closely related to the STDP mechanisms. Based on this simulation work, the cell circuit with neurons and synaptic circuit which can simulate the information processing mechanisms of biological nervous system will be further built, then the electronic circuits with adaptive robustness will be designed based on the cell circuit.